About CYTOCON

CYTOCON (Cell and cYTOkine CONcentrations) is an initiative project undertaken by InSysBio UK team and aimed at the development of a database that allows collecting, processing and visualizing publicly available data on immune cells and cytokine baseline concentrations in humans.

CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues of healthy subjects and patients suffering from various pathologies.

CYTOCON team makes an effort in two directions: the collection and processing of appropriate data on human immune cell and cytokine concentrations available in public domain (content of CYTOCON DB) and the development of tools/methods for processing, extraction and visualization of the data (CYTOCON DB).

Key features of CYTOCON DB

Search for cell/cytokine concentration for selected disease, tissue (or a group of diseases and tissues), patient group.
Search query for cell concentration may include a list of cell markers: i.e. for Th2-cell - CD4+, IL4+
Search query may include following patient group attributes:
- demographic characteristics (age, race, gender, etc);
- number of patients in the study.
Search query may take into account disease-specific clinically measured characteristics, for example:
- Asthma: FEV1;
- SLE: SLEDAI range, interferon signature;
- Atopic Dermatitis: SCORAD range, severity, range of IgE concentration;
- etc.
Unification of measurement units: conversion of source original units to “pM” for cytokine and “kcell/L” for cell concentration.
Table representation of search results: average value and dispersion of concentration of cell/cytokine in original and unified units, tissue type, data source, patient group and disease attributes are specified.
Export of search results in csv format

Content of CYTOCON DB

0 disease types, press to view details;

0 tissues/physiological fluids, press to view details;

0 molecules (cytokines, chemokines, growth factors, other molecules like PGE2, LTE4 etc), press to view details;

0 cell types and states, press to view details;

0 values of cytokine/cell concentrations;
data extracted from 0 papers/other public sources.

Counts cover articles in the Done state (same as Supplementary → Additional info) and are cached for 10 minutes.

CYTOCON DB is developed as a web application based on ASP.NET Core. The data warehouse is Microsoft SQL Server or PostgreSQL. The user interface uses Telerik Kendo UI and Bootstrap.

Versions of the database

Commercial version entitled as “CYTOCON DB”
Public version entitled as “CYTOCON DB Open”

To arrange the purchase of the commercial license, please contact support@insysbio.com. The public Open version is available at cytocon-open.insysbio.com.